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KMID : 0624620220550110559
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BMB Reports
2022 Volume.55 No. 11 p.559 ~ p.564
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Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus
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Ryu Yeong-Chan
Kim You-rin
Park Ji-Yeon
Choi Se-Hee
Kim Geon-Uk
Kim Eun-Hwan
Hwang Yu-Mi
Kim Hee-Jene
Bak Soon-Sun
Lee Jin-Eun
Sung Young-Kwan
Han Gyoon-Hee
Lee Soung-Hoon
Choi Kang-Yell
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Abstract
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Diabetes mellitus is one of the most prevalent diseases in modern society. Many complicationssuch as hepatic cirrhosis, neuropathy, cardiac infarction, and so on are associated with diabetes. Although a relationship between diabetes and hair loss has been recently reported, the treatment of diabetic hair loss by Wnt/β-catenin activators has not been achieved yet. In this study, we found that the depilation-induced anagen phase was delayed in both db/db mice and high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice. In diabetic mice, both hair regrowth and wound-induced hair follicle neogenesis (WIHN) were reduced because of suppression of Wnt/β-catenin signaling and decreased proliferation of hair follicle cells. We identified that KY19382, a small molecule that activates Wnt/β-catenin signaling, restored the capabilities of regrowth and WIHN in diabetic mice. The Wnt/β-catenin signaling activator also increased the length of the human hair follicle which was decreased under high glucose culture conditions. Overall, the diabetic condition reduced both hair regrowth and regeneration with suppression of the Wnt/β-catenin signaling pathway. Consequently, the usage of Wnt/β-catenin signaling activators could be a potential strategy to treat diabetes-induced alopecia patients.
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KEYWORD
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Diabetes mellitus, Hair induction capability, Hair loss, Wnt/β-catenin signaling, Wound-induced hair follicle neogenesis
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